Voxel-based morphometry of adulthood patients with temporal lobe epilepsy

Background Partial epilepsy represents almost 70% of the epileptic syndrome. It is characterized by partial seizures that arise from the restricted area of the cerebral cortex. Temporal lobe epilepsy (TLE) is the most frequent form of cryptogenic partial epilepsies [1]. The mesial temporal sclerosis is the pathologic abnormality most frequently detected in post mortem studies of subjects with TLE. Voxel-based morphometry (VBM) is a new MRI tool that has been developed to assess differences of brain tissue volumes between subject groups and has been applied in various studies of patients with TLE [2]. In refractory TLE (rTLE) gray (GM) and white (WM) matter abnormalities are not confined to the hippocampus but also are found in extrahippocampal structures [3]. Less is known about mild TLE (mTLE). In the present work, we used optimized voxel-based morphometry (VBM) to identify GM abnormalities beyond the hippocampus in rTLE and in mTLE with evidence of hippocampal sclerosis (HS).